Perilymphatic Signal Changes in Vestibular Schwannoma: A Potential Biomarker of Progressive Hearing Loss?

IF 2.5 3区医学 Q1 OTORHINOLARYNGOLOGY Otolaryngology- Head and Neck Surgery Pub Date : 2025-07-01 Epub Date: 2025-03-19 DOI:10.1002/ohn.1228

Anne Renée Juliette Péporté, Benoît Gallix, Aïna Venkatasamy

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Abstract

Objective: Vestibular schwannomas influence the magnetic resonance (MR) signal intensity (SI) in the vestibular cistern and cochlear perilymph. The aim of this study is to evaluate the relationship between perilymphatic signal changes on gradient-echo T2-weighted 3 T MR sequence and the clinical symptoms.

Study design: Retrospective case-control study.

Setting: The study was conducted at the Institute of Image-Guided Surgery in Strasbourg, France.

Methods: Patients with vestibular schwannoma who underwent magnetic resonance imaging at our institution between 2008 and 2016 were retrospectively reviewed. A control group consisted of individuals without past or present otological symptoms. The vestibular schwannomas were divided into three groups, based on the degree of internal auditory canal obstruction. The SI ratios of the vestibular cistern to cerebrospinal fluid (CSF) and cochlea to CSF were compared with clinical data.

Results: We included 172 patients with vestibular schwannoma and 61 controls. Vestibular schwannoma was associated with a significant decrease of the SI ratio of the vestibular cistern to CSF (0.716 ± 0.297 vs 1.06 ± 0.21, P = .004) and cochlea to CSF (0.66 ± 0.199 vs 0.903 ± 0.011, P = .004) compared to controls, with significant negative correlation between both the SI ratios of the vestibular cistern and cochlea to CSF with tumor volume (P < .001). Among all the symptoms studied, the SI ratio of the cistern normalized by CSF was significantly associated with progressive hearing loss (P = .003).

Conclusion: Perilymphatic vestibular cistern and cochlear SI changes appear to be a promising noninvasive biomarker for hearing impairment in vestibular schwannoma.

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前庭神经鞘瘤的淋巴周围信号改变：进行性听力损失的潜在生物标志物？

目的：探讨前庭神经鞘瘤对前庭池及耳蜗淋巴周围核磁共振信号强度的影响。本研究的目的是评估梯度回声t2加权3t MR序列淋巴周围信号变化与临床症状的关系。研究设计：回顾性病例对照研究。背景：该研究在法国斯特拉斯堡的影像引导外科研究所进行。方法：回顾性分析2008年至2016年在我院行磁共振成像的前庭神经鞘瘤患者。对照组由过去或现在没有耳科症状的个体组成。根据内耳道阻塞程度将前庭神经鞘瘤分为三组。将前庭池与脑脊液、耳蜗与脑脊液的比值与临床资料进行比较。结果：我们纳入了172例前庭神经鞘瘤患者和61例对照组。前庭神经鞘瘤与对照组相比，前庭池与脑脊液的比值（0.716±0.297 vs 1.06±0.21,P = 0.004）和耳蜗与脑脊液的比值（0.66±0.199 vs 0.903±0.011,P = 0.004）显著降低，且前庭池和耳蜗与脑脊液的比值与肿瘤体积呈显著负相关(P)。淋巴管周围前庭池和耳蜗SI的改变似乎是前庭神经鞘瘤听力损伤的一种有前途的非侵入性生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.