[Features of cardiometabolic risk in elderly patients with osteoarthritis.]

Abstract

The article presents the relationship between cardiovascular and metabolic disorders (lipid and carbohydrate metabolism) in elderly patients with osteoarthritis. The aim of the work was to determine the frequency of modifiable cardiometabolic risk factors in elderly people with knee osteoarthritis, depending on the severity of osteoarthritis and sexual dimorphism. The study included 154 elderly patients (67,3±4,2 years) with osteoarthritis of the knee joint (КOA). In a comparative analysis, taking into account the severity of КOA, it was found that patients with grade 3 КOA (according to Kellgren-Lawrence) we're more involved to have obesity (25,2%, p<0,01), arterial hypertension (AH) (15,1% p<0,05), diabetes mellitus (DM) (27,1%, p<0,01), smoking (94%, p<0,001), LDL cholesterol (32.7%, p<0,01), triglycerides (26,8%, p<0,01), impaired glucose tolerance (by 18,4%, p<0,01), high (14.4%, p<0,05) and very high (59,2%, p<0,001) the degree of risk on the SCORE-OР scale compared with patients with grade 2 according to Kellgren-Lawrence. When comparing patients, depending on sexual dimorphism, it was revealed that in elderly men with grade 3 КOA (according to Kellgren-Lawrence), 42,7% (p<0,001), obesity (15,1%, p<0,05), elevated LDL cholesterol (37,8%, p<0,01) were more common compared with women, while women's leptin levels were 23,9% higher (p<0,01). Against the background of the therapy, men we're more involved to have hypertension by 21,4% (p<0,01), diabetes by 36,7% (p<0,01) and a very high risk on the SCORE-ОР scale by 75,5% (p<0,001) compared with women.