Prognostic Value of the Vascular Lake Phenomenon in Large Hepatocellular Carcinoma Following Conventional TACE: A Retrospective Study.

IF 3.8 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Academic Radiology Pub Date : 2025-03-17 DOI:10.1016/j.acra.2025.02.020

Zhi-Hui Hong, Hai-Feng Zhou, Wei Yang, Wei-Zhong Zhou

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引用次数: 0

Abstract

Rationale and objectives: The study aimed to evaluate risk factors related to the vascular lake phenomenon (VLP) and its impact on prognosis in patients with large hepatocellular carcinoma (HCC) (≥5 cm) undergoing Conventional transarterial chemoembolization (cTACE).

Patients and methods: This study included 149 patients with large HCC who initially underwent cTACE from July 2021 to July 2023. The univariate and multivariate analyses were conducted to find risk factors related to VLP. The overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and postoperative complications were compared between the VLP group and the non-VLP group. The propensity score matching (PSM) was used to reduce selection bias.

Results: Among the 149 patients (mean age 65±12 years; 120 male), 50 patients were in the VLP group. The VLP group had a significantly higher positive rate of Hepatitis B surface Antigen (HBsAg) (p=.006). After PSM, VLP was an independent factor associated with OS (p=.002, HR 0.39, 95% CI: 0.21, 0.72) and PFS (p=.002, HR 0.50, 95% CI: 0.32, 0.78). The VLP group showed significantly longer OS (19.1 months vs. 13.4 months, p=.005), longer PFS (11.2 months vs. 6.5 months, p=.006), higher ORR (34.0% vs 14.0%, p=.019), and higher DCR (62.0% vs 26.0%, p<.001) than the non-VLP group.

Conclusion: The presence of VLP in large HCC may correlate with a higher rate of HBsAg positivity. It can indicate improved survival outcomes and treatment response underwent cTACE treatment.

Summary: In hepatocellular carcinoma with a diameter greater than 5 cm, the presence of preoperative vascular lake phenomenon indicates better transarterial chemoembolization efficacy.

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.