Charly Abi-Ghanem, Richard D. Kelly, Emily A. Groom, Caitlin G. Valerian, Aaron S. Paul, Christina A. Thrasher, Abigail E. Salinero, Molly R. Batchelder, Jennifer J Lafrican, Matthew Wang, Rachel M. Smith, Sally Temple, Damian G. Zuloaga, Kristen L. Zuloaga
{"title":"Interactions between menopause and high-fat diet on cognition and pathology in a mouse model of Alzheimer's disease","authors":"Charly Abi-Ghanem, Richard D. Kelly, Emily A. Groom, Caitlin G. Valerian, Aaron S. Paul, Christina A. Thrasher, Abigail E. Salinero, Molly R. Batchelder, Jennifer J Lafrican, Matthew Wang, Rachel M. Smith, Sally Temple, Damian G. Zuloaga, Kristen L. Zuloaga","doi":"10.1002/alz.70026","DOIUrl":null,"url":null,"abstract":"Post-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"126 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.70026","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Post-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on cognitive and pathological outcomes in an AD mouse model.
期刊介绍:
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.