Kelsey R. Sewell, Lauren E. Oberlin, Thomas K. Karikari, Marcos Olvera-Rojas, Lu Wan, Jill K. Morris, Paul J. Kueck, Xuemei Zeng, Haiqing Huang, George Grove, Yijun Chen, Tara K. Lafferty, Anuradha Sehrawat, M. Ilyas Kamboh, Anna L. Marsland, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Chaeryon Kang, Kirk I. Erickson
{"title":"Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits","authors":"Kelsey R. Sewell, Lauren E. Oberlin, Thomas K. Karikari, Marcos Olvera-Rojas, Lu Wan, Jill K. Morris, Paul J. Kueck, Xuemei Zeng, Haiqing Huang, George Grove, Yijun Chen, Tara K. Lafferty, Anuradha Sehrawat, M. Ilyas Kamboh, Anna L. Marsland, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Chaeryon Kang, Kirk I. Erickson","doi":"10.1002/alz.14619","DOIUrl":null,"url":null,"abstract":"The utility of blood-based biomarkers for discriminating Alzheimer's disease (AD)-related versus non-AD-related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood markers to detect and discriminate variation in performance across multiple cognitive domains in a cognitively unimpaired sample.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.14619","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The utility of blood-based biomarkers for discriminating Alzheimer's disease (AD)-related versus non-AD-related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability of blood markers to detect and discriminate variation in performance across multiple cognitive domains in a cognitively unimpaired sample.
期刊介绍:
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.