Olivia Wagemann, Georg Nübling, Francisco Jesús Martínez-Murcia, Elisabeth Wlasich, Sandra V. Loosli, Katja Sandkühler, Anna Stockbauer, Catharina Prix, Sabrina Katzdobler, Agnese Petrera, Stefanie M. Hauck, Juan Fortea, Rocío Romero-Zaliz, Carmen Jiménez-Mesa, Juan M. Górriz Sáez, Günter Höglinger, Johannes Levin
{"title":"Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's disease","authors":"Olivia Wagemann, Georg Nübling, Francisco Jesús Martínez-Murcia, Elisabeth Wlasich, Sandra V. Loosli, Katja Sandkühler, Anna Stockbauer, Catharina Prix, Sabrina Katzdobler, Agnese Petrera, Stefanie M. Hauck, Juan Fortea, Rocío Romero-Zaliz, Carmen Jiménez-Mesa, Juan M. Górriz Sáez, Günter Höglinger, Johannes Levin","doi":"10.1002/alz.70040","DOIUrl":null,"url":null,"abstract":"Adults with Down syndrome (DS) show increased risk for Alzheimer's disease (AD) due to the triplication of chromosome 21 encoding the <i>amyloid precursor protein</i> gene. Further, this triplication possibly contributes to dysregulation of the immune system, furthering AD pathophysiology.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"61 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.70040","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Adults with Down syndrome (DS) show increased risk for Alzheimer's disease (AD) due to the triplication of chromosome 21 encoding the amyloid precursor protein gene. Further, this triplication possibly contributes to dysregulation of the immune system, furthering AD pathophysiology.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
