{"title":"GWAS scorecard prioritizes kidney genes using coding and regulatory variants","authors":"Matthias Wuttke, Cristian Pattaro","doi":"10.1038/s41581-025-00952-3","DOIUrl":null,"url":null,"abstract":"Based on genome-wide association study data from 2.2 million individuals, a functional prioritization scorecard integrates classical omics with allele-specific gene expression, chromatin accessibility and gene regulatory circuits in kidney tissues and specific cell types. This approach prioritized 601 kidney function-related genes, including genes associated with nephropathy in mice and humans.","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"366 1","pages":""},"PeriodicalIF":28.6000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41581-025-00952-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Based on genome-wide association study data from 2.2 million individuals, a functional prioritization scorecard integrates classical omics with allele-specific gene expression, chromatin accessibility and gene regulatory circuits in kidney tissues and specific cell types. This approach prioritized 601 kidney function-related genes, including genes associated with nephropathy in mice and humans.
期刊介绍：
Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves.
It strives to publish authoritative, accessible articles.
Articles are enhanced with clearly understandable figures, tables, and other display items.
Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements.
The content is relevant to nephrologists and basic science researchers.
The broad scope of the journal ensures that the work reaches the widest possible audience.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
