The effect of tart cherry juice (TCJ) supplementation on exercise-induced muscle damage (EIMD) in an athletic population.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Annals of Medicine and Surgery Pub Date : 2025-01-21 eCollection Date: 2025-02-01 DOI:10.1097/MS9.0000000000002914

Elaheh Dehghani, Mohammad Beba, Khashayar Danandeh, Amirhossein Memari, Mohamad Javad Ershadmanesh, Pegah Rasoulian, Arshiya Danandeh, Kurosh Djafarian

{"title":"The effect of tart cherry juice (TCJ) supplementation on exercise-induced muscle damage (EIMD) in an athletic population.","authors":"Elaheh Dehghani, Mohammad Beba, Khashayar Danandeh, Amirhossein Memari, Mohamad Javad Ershadmanesh, Pegah Rasoulian, Arshiya Danandeh, Kurosh Djafarian","doi":"10.1097/MS9.0000000000002914","DOIUrl":null,"url":null,"abstract":"Introduction: This systematic review and meta-analysis quantified the effect of tart cherry juice (TCJ) supplementation on exercise-induced muscle damage (EIMD). Evidence supported TCJ's beneficial effects on muscular function and inflammatory biomarkers interleukin (IL)-6 and IL-8.Method: PubMed, Scopus, and Web of Science were searched up to January 2024. Risk of bias was assessed using RevMan® software. Mean differences and 95% confidence intervals (CIs) of maximal voluntary isometric contraction (MVIC), inflammatory markers, creatine kinase (CK), and visual analog scale (VAS) score were pooled using fixed- or random-effect models. Heterogeneity was assessed using Chi-square or I 2 statistics.Results: Ten trials were included in the analysis. TCJ supplementation significantly improved MVIC [weighted mean difference (WMD) = 9.13%, 95% CI (6.42-11.84), I 2 = 62.3%] and decreased IL-6 [WMD = -0.4 pg/ml, 95% CI (-0.68 to -0.11), I 2 = 62.2%] and IL-8 [WMD = -0.3 pg/ml, 95% CI (-0.6 to -0.0), I 2 = 46.3%]. No significant changes were found in CK, C-reactive protein, IL-1β, tumor necrosis factor-alpha, or VAS score. Dose-response analysis revealed a significant non-linear association between daily TCJ dose and MVIC effect size.Conclusion: TCJ supplementation may improve muscle function and some inflammatory biomarkers in EIMD. Further high-quality studies with larger sample sizes are needed to determine TCJ's long-term effects.","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 2","pages":"880-890"},"PeriodicalIF":1.7000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918606/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Medicine and Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/MS9.0000000000002914","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: This systematic review and meta-analysis quantified the effect of tart cherry juice (TCJ) supplementation on exercise-induced muscle damage (EIMD). Evidence supported TCJ's beneficial effects on muscular function and inflammatory biomarkers interleukin (IL)-6 and IL-8.

Method: PubMed, Scopus, and Web of Science were searched up to January 2024. Risk of bias was assessed using RevMan® software. Mean differences and 95% confidence intervals (CIs) of maximal voluntary isometric contraction (MVIC), inflammatory markers, creatine kinase (CK), and visual analog scale (VAS) score were pooled using fixed- or random-effect models. Heterogeneity was assessed using Chi-square or I ² statistics.

Results: Ten trials were included in the analysis. TCJ supplementation significantly improved MVIC [weighted mean difference (WMD) = 9.13%, 95% CI (6.42-11.84), I ² = 62.3%] and decreased IL-6 [WMD = -0.4 pg/ml, 95% CI (-0.68 to -0.11), I ² = 62.2%] and IL-8 [WMD = -0.3 pg/ml, 95% CI (-0.6 to -0.0), I ² = 46.3%]. No significant changes were found in CK, C-reactive protein, IL-1β, tumor necrosis factor-alpha, or VAS score. Dose-response analysis revealed a significant non-linear association between daily TCJ dose and MVIC effect size.

Conclusion: TCJ supplementation may improve muscle function and some inflammatory biomarkers in EIMD. Further high-quality studies with larger sample sizes are needed to determine TCJ's long-term effects.

查看原文