Enhanced Drug Effect With Cutting Balloon Followed by Drug Coated Balloon in a Rabbit Model

IF 1.9 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Catheterization and Cardiovascular Interventions Pub Date : 2025-03-20 DOI:10.1002/ccd.31505

Manabu Shiozaki, Sho Torii, Yu Sato, Kazuki Aihara, Yuki Matsumoto, Norihito Nakamura, Daiki Suzuki, Ayako Yoshikawa, Yuji Ikari, Gaku Nakazawa

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Abstract

Background

Drug-coated balloon (DCB) are effective treatment options for patients with coronary artery disease and using of scoring or cutting balloon before the DCB usage were recommended. However, the effectiveness of lesion preparation with cutting balloons (CB) followed by DCB (CB + DCB) has not been evaluated before.

Aims

The aim of the current study was to compare the biological effect of various types of balloon angioplasty in a healthy rabbit iliac artery model.

Methods

Each of the four kinds of treatments as balloon angioplasty (BA), CB alone, DCB alone, and CB + DCB were performed in the healthy iliac arteries of 12 rabbits, which were euthanized after 14 days. The treated iliac arteries were sequentially cut, stained with hematoxylin and eosin and Movat Pentachrome, and histopathologically evaluated.

Results

The depth of medial smooth muscle cell (SMC) loss score, an indicator of drug effect, was highest with CB + DCB, followed by DCB, CB, and BA (CB + DCB vs. DCB vs. CB vs. BA: 3.83 (3.67–4.00) vs. 3.17 (2.67–3.67), 1.67 (1.67–2.08) vs. 1.50 (1.00–1.67), p < 0.0001). The angle with severe SMC loss was also the highest with CB + DCB group, followed by DCB group, CB group, and BA group (123.7 (104.5–132.2) vs. 52.1 (34.7–100.6), 0.0 (0.0–14.2) vs. 0.0 (0.0–0.0), respectively, p < 0.0001), suggesting a higher drug effect in CB + DCB compared with DCB alone.

Conclusions

The drug effect of DCB was enhanced when CB was used before DCB treatment, suggesting the effectiveness of the combination therapy of CB and DCB.

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切球囊后涂药球囊增强兔模型药物效果。

背景：药物包被球囊（Drug-coated balloon， DCB）是冠状动脉疾病患者有效的治疗选择，建议在使用药物包被球囊前使用记分或切割球囊。然而，切球囊（CB）预备病变后再行DCB （CB + DCB）的有效性尚未得到评价。目的：本研究的目的是比较不同类型球囊血管成形术在健康家兔髂动脉模型中的生物学效果。方法：采用球囊血管成形术（BA）、CB单用、DCB单用、CB + DCB四种治疗方法，分别对12只家兔健康髂动脉进行处理，14 d后安乐死。治疗后的髂动脉依次切开，苏木精、伊红和莫瓦五色染色，并进行组织病理学评价。结果：CB + DCB组疗效指标内侧平滑肌细胞深度（SMC）损失评分最高，其次为DCB、CB、BA (CB + DCB vs. DCB vs. CB vs. BA: 3.83 (3.67-4.00) vs. 3.17 (2.67-3.67), 1.67 (1.67-2.08) vs. 1.50 (1.00-1.67)， p结论：在DCB治疗前使用CB可增强DCB的疗效，提示CB与DCB联合治疗的有效性。

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来源期刊

Catheterization and Cardiovascular Interventions 医学-心血管系统

CiteScore

5.40

自引率

8.70%

发文量

419

审稿时长

2 months

期刊介绍： Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.

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