Comparative Phytochemical Insights and Potential Bioactivities of Phyllodium pulchellum Leaf and Bract Extracts

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2025-03-20 DOI:10.1002/cbdv.202403458

Adwaita Das, Moitri Bhadra, Sunanda Burman, Goutam Chandra, Abhijit Bandhyopadhyay

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Abstract

Phyllodium pulchellum (L.) Desv., a little-explored medicinal plant of the family Papilionoideae, is a deciduous woody shrub with large circular bifoliolate and persistent leafy bracts. The present investigation compares the phytochemical profile of methanolic extracts of P. pulchellum leaf (PPL) and green leafy bract (P. pulchellum bract [PPB]) using HRLCMS and their antioxidant and antimicrobial activities. Interestingly, PPB extract revealed higher contents of phenol and flavonoids and behaved as a potent free radical scavenger in both DPPH (IC₅₀ = 15.96 ± 0.67 µg/mL) and ABTS (IC₅₀ = 56.18 ± 1.7 µg/mL) assays. Furthermore, PPB shows a prominent antimicrobial impact on four different human pathogenic bacterial strains. From in silico investigation, it is evident that the methanolic extracts of PPB and PPL have a positive correlation with antibacterial activity. Methanolic PPL and PPB extracts yielded 55 chemical components, including many novel and unidentified phytocompounds. Molecular docking approach is adopted to examine the antibacterial qualities of isolated phytometabolites, which offers untapped therapeutic potential of these compounds.

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叶根叶和苞片提取物的植物化学比较研究及潜在生物活性研究。

叶根（Phyllodium pulchellum）Desv。家庭的,一个多的药用植物Papilionoideae落叶木本灌木与大圆形bifoliolate和持久的叶苞片。本研究采用HR-LCMS法比较了白皮叶（PPL）和绿叶苞片（PPB）甲醇提取物的植物化学特征，以及它们的抗氧化和抗菌活性。在DPPH （IC50 = 15.96±0.67 μg/ml）和ABTS （IC50 = 56.18±1.7 μg/ml）试验中，PPB提取物显示出较高的酚类和类黄酮含量，并具有较强的自由基清除能力。此外，PPB对四种不同的人类致病菌菌株具有显著的抗菌作用。实验结果表明，PPB和PPL的甲醇提取物与抗菌活性呈正相关。甲醇PPL和PPB提取物产生55种化学成分，包括许多新的和未知的植物化合物。采用分子对接的方法对分离的植物代谢物的抗菌特性进行检测，为这些化合物提供了尚未开发的治疗潜力。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.