Feasibility of magnetic resonance elastography in the healthy rat heart.

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance in Medicine Pub Date : 2025-03-19 DOI:10.1002/mrm.30504

Lisa Smith, Vidar Magne Skulberg, Lili Zhang, Ivar Sjaastad, Emil Knut Stenersen Espe

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Abstract

Purpose: Develop a MR elastography (MRE) protocol to detect in vivo cardiac stiffness in rats.

Methods: This study was approved by the National Animal Research Authority. A healthy, adult, male Sprague-Dawley rat underwent cardiac MRE. A specialized direct shaking cardiac MRE setup and MRI protocol were designed. Stiffness was measured at 15 cardiac phases. A single midventricular slice was acquired, and intrasession variability was measured. A direct inversion of the Helmholtz equation was used to calculate the stiffness from MRE images.

Results: In the healthy rat, the early systolic stiffness was 2.90 kPa. The stiffness increased to the end systole (3.81 kPa), followed by a reduction during diastole to 2.61 kPa. The intrasession correlation was ρ = 0.88 (p < 0.001).

Conclusion: This study demonstrates the feasibility of cardiac MRE in rats. Our results confirm that cardiac stiffness increases from early systole to end systole, followed by a decrease in diastole.

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.