Prokineticin-2 and Procalcitonin's Diagnostic Accuracy for Sepsis in Critically Ill Patients: A Prospective Observational Study.

Abstract

Objective: Sepsis stands as a significant contributor to mortality in ICU settings worldwide. Early diagnosis and appropriate treatment are therefore essential to reduce mortality. We planned this study to investigate the diagnostic significance of prokineticin-2 (PK-2) in patients with sepsis.

Materials and methods: Adult patients with sepsis who were admitted to our intensive care unit (ICU) were included in this prospective observational study. On the day of admission and the 7th day of the ICU stay, the levels of procalcitonin (PCT) and PK-2 were assessed. Patients' mortality was observed for 28 days.

Results: This research involved 83 patients meeting the inclusion criteria. Prokineticin-2 showed a diagnostic sensitivity of 70.6% for sepsis, outperforming PCT with a sensitivity of 64.7%. In predicting mortality, PCT displayed a sensitivity of 95.5%, whereas Prokineticin-2 demonstrated an even higher sensitivity at 98.4%.

Conclusion: Prokinectin-2 can be used for screening adult patients with sepsis admitted to ICU.

How to cite this article: Bhat K, Kothari N, Sharma A, Goyal S, Meshram T, Paliwal B, et al. Prokineticin-2 and Procalcitonin's Diagnostic Accuracy for Sepsis In Critically Ill Patients: A Prospective Observational Study. Indian J Crit Care Med 2025;29(3):268-272.