Trends in Benzodiazepine and Z-Drug Prescriptions in Eastern China (2015-2021).

Abstract

Objective: This study analyses trends in the prescription and usage of benzodiazepines (BZDs) and Z-drugs within specialised medical institutions and emergency outpatient services in China from 2015 to 2021, focusing on demographics and prescribing patterns to promote better management practices.

Methods: A retrospective study was conducted from 2015 to 2021, reviewing prescription information and population characteristics from 10 hospitals, including specialised psychiatric institutions and general hospitals in Zhejiang, Jiangsu, and Shanghai. The study analysed a total of 33,569 valid prescriptions.

Results: There was a noticeable increase in the total defined daily doses of both benzodiazepines and Z-drugs, with significant variations among different drugs. Lorazepam and zopiclone showed the most substantial increases in usage. Drugs like clonazepam and lorazepam were predominantly prescribed, indicating specific patterns in disease management, particularly for insomnia and anxiety.

Conclusions: This study reveals a significant increase in benzodiazepine and Z-drug prescriptions, particularly among elderly and female patients. The findings highlight the need for targeted interventions and policy reforms to ensure safe prescribing practices and mitigate the risks associated with long-term use in these vulnerable populations.