{"title":"Interplay of somatic mutations and epigenetic aging clocks","authors":"Wolfgang Wagner","doi":"10.1038/s43587-025-00846-w","DOIUrl":null,"url":null,"abstract":"The aging process is influenced by several factors, including the accumulation of mutations and the acquisition of epigenetic alterations throughout life. A recent study by Koch and colleagues demonstrates that these seemingly independent mechanisms interact: somatic mutations affect DNA methylation and epigenetic age predictions.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 4","pages":"536-538"},"PeriodicalIF":19.4000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00846-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The aging process is influenced by several factors, including the accumulation of mutations and the acquisition of epigenetic alterations throughout life. A recent study by Koch and colleagues demonstrates that these seemingly independent mechanisms interact: somatic mutations affect DNA methylation and epigenetic age predictions.
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