The associations among maternal gestational weight gain, cord blood DNA methylation, and offspring childhood high BMI

IF 4.7 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2025-03-19 DOI:10.1002/oby.24257

Yuanyuan Zhang, Hong Mei, Ruixia Chang, Chunan Li, Hongzhong Zhang, Jianduan Zhang

{"title":"The associations among maternal gestational weight gain, cord blood DNA methylation, and offspring childhood high BMI","authors":"Yuanyuan Zhang, Hong Mei, Ruixia Chang, Chunan Li, Hongzhong Zhang, Jianduan Zhang","doi":"10.1002/oby.24257","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The objective of this study was to explore the associations among maternal gestational weight gain (GWG), cord blood DNA methylation, and high BMI.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Using the Illumina Infinium MethylationEPIC Bead Chip, GWG-related methylation sites were screened in 40 cord blood samples using a cohort design, and the association of these sites with children's BMI status at 3 years was examined. Sites simultaneously related to GWG and children's BMI were validated in an external dataset. The mediation effect of target differential methylation probes in the association between GWG and children's BMI was also explored.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>We identified 66 GWG-related differential methylation probes in cord blood, and four sites, including cg09973771 (<i>SNTG2</i>), cg00254258 (<i>PRDM16</i>), cg02672830 (<i>MCPH1</i>), and cg15424377, were found to be associated with children's BMI at age 3 years. The mediating effect of cord blood DNA methylation was not detected in the association between GWG and children's high BMI status. Out of the four sites screened, methylation level of site cg09973771 (<i>SNTG2</i>) in peripheral blood showed nominal significant differences among children with different BMI statuses at age 3 years.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Maternal GWG and childhood BMI status at age 3 years were associated with newborn cord blood DNA methylation.</p>\n </section>\n </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 4","pages":"766-776"},"PeriodicalIF":4.7000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/oby.24257","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

The objective of this study was to explore the associations among maternal gestational weight gain (GWG), cord blood DNA methylation, and high BMI.

Methods

Using the Illumina Infinium MethylationEPIC Bead Chip, GWG-related methylation sites were screened in 40 cord blood samples using a cohort design, and the association of these sites with children's BMI status at 3 years was examined. Sites simultaneously related to GWG and children's BMI were validated in an external dataset. The mediation effect of target differential methylation probes in the association between GWG and children's BMI was also explored.

Results

We identified 66 GWG-related differential methylation probes in cord blood, and four sites, including cg09973771 (SNTG2), cg00254258 (PRDM16), cg02672830 (MCPH1), and cg15424377, were found to be associated with children's BMI at age 3 years. The mediating effect of cord blood DNA methylation was not detected in the association between GWG and children's high BMI status. Out of the four sites screened, methylation level of site cg09973771 (SNTG2) in peripheral blood showed nominal significant differences among children with different BMI statuses at age 3 years.

Conclusions

Maternal GWG and childhood BMI status at age 3 years were associated with newborn cord blood DNA methylation.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

母亲妊娠期体重增加、脐带血DNA甲基化和后代儿童期高BMI之间的关系。

目的：本研究的目的是探讨母亲妊娠期体重增加（GWG）、脐带血DNA甲基化和高BMI之间的关系。方法：使用Illumina Infinium MethylationEPIC芯片，采用队列设计筛选40份脐带血样本中与gwg相关的甲基化位点，并研究这些位点与3岁儿童BMI状况的关系。同时与GWG和儿童BMI相关的站点在外部数据集中进行了验证。并探讨了靶差异甲基化探针在GWG与儿童BMI之间的中介作用。结果：我们在脐带血中鉴定了66个与gwg相关的差异甲基化探针，发现cg09973771 （SNTG2）、cg00254258 （PRDM16）、cg02672830 （MCPH1）和cg15424377四个位点与3岁儿童BMI相关。脐带血DNA甲基化在GWG与儿童高BMI状态之间的关联中未检测到介导作用。在筛选的四个位点中，3岁时不同BMI状态的儿童外周血中cg09973771位点（SNTG2）的甲基化水平显示出名义上的显著差异。结论：母亲GWG和3岁时儿童BMI状况与新生儿脐带血DNA甲基化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.