The Protein Design Archive (PDA): insights from 40 years of protein design

IF 41.7 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2025-03-21 DOI:10.1038/s41587-025-02607-x
Marta Chronowska, Michael J. Stam, Derek N. Woolfson, Luigi F. Di Costanzo, Christopher W. Wood
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蛋白质设计档案(PDA): 40年来蛋白质设计的见解
虽然天然蛋白质是多种多样的生物大分子,但它们只呈现了化学上可能的序列和结构空间的一个子集。蛋白质设计领域有潜力照亮这一领域尚未探索的领域,加深我们对序列-结构-功能关系的理解,并使开发可用于解决社会挑战的新型蛋白质成为可能。在过去的40年里,蛋白质设计从理性设计到当代数据驱动的方法已经发生了巨大的变化。这个领域现在已经达到了里程碑式的成就,比如设计了小分子和蛋白质的结合物,创造了全新的折叠方式,并获得了诺贝尔奖。然而,很难确定该领域当前的挑战和机遇,因为没有容易搜索的资源提供迄今为止已设计的蛋白质的概述。这样的资源将提高我们从以前的努力中学习的能力,并指导未来设计方法的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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