{"title":"A cut above: Bacterial deubiquitinases with ubiquitin clippase activity","authors":"Mark Hochstrasser","doi":"10.1016/j.molcel.2025.02.023","DOIUrl":null,"url":null,"abstract":"Pathogenic or symbiotic bacteria residing inside eukaryotic cells often foil attempts to eliminate them by secreting deubiquitinases into the host. In this issue of <em>Molecular Cell</em>, Hermanns et al.<span><span><sup>1</sup></span></span> uncover an unexpected “clippase” activity in certain bacterial deubiquitinases, which cleaves substrate-linked ubiquitin within the ubiquitin C terminus, thereby inactivating it.","PeriodicalId":18950,"journal":{"name":"Molecular Cell","volume":"19 1","pages":""},"PeriodicalIF":14.5000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.molcel.2025.02.023","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pathogenic or symbiotic bacteria residing inside eukaryotic cells often foil attempts to eliminate them by secreting deubiquitinases into the host. In this issue of Molecular Cell, Hermanns et al.1 uncover an unexpected “clippase” activity in certain bacterial deubiquitinases, which cleaves substrate-linked ubiquitin within the ubiquitin C terminus, thereby inactivating it.
期刊介绍：
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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