Investigation of the Effect of Preconditioning with Ultrasound on Fat Graft Survival

IF 2.8 3区 医学 Q2 SURGERY Aesthetic Plastic Surgery Pub Date : 2025-03-20 DOI:10.1007/s00266-025-04771-6
Arif Yılmaz, Bilge Kağan Yılmaz, Çiğdem Karaca, Necmettin Karasu
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Abstract

Background

The use of fat grafts in plastic, reconstructive, and aesthetic surgery has been increasing. Although fat grafting has many advantages, there is limited evidence regarding its survival rates. Current studies focus on improving fat graft survival rates. This study aimed to evaluate the effect of therapeutic ultrasound (TERUS) application on fat graft survival.

Methods

The study involved 42 adult male Wistar Albino rats, which were randomly divided into seven groups of six rats each: Group 1 served as the control group and received only fat grafting; Group 2 received preoperative daily TERUS for one week, followed by fat grafting; Group 3 underwent preoperative daily massage for one week, followed by fat grafting; Group 4 received preoperative daily TERUS for one week, followed by fat grafting and postoperative daily TERUS for one week; Group 5 underwent preoperative daily massage for one week, followed by fat grafting and postoperative daily massage for one week; Group 6 received postoperative daily TERUS for one week; and Group 7 received postoperative daily massage for one week. After volume and weight measurements, immunohistochemical evaluation was conducted using perilipin and PECAM-1. Apoptosis was assessed using the TUNEL method.

Results

No statistically significant differences were observed in the macroscopic measurements. While TERUS increased the vascularization of fat grafts, it did not improve survival rates. The mean fat graft survival rate in the preoperative–postoperative massage group (Group 5) was statistically significantly higher than in the other groups.

Conclusions

The findings of this study suggest that the massage effect of TERUS, independent of ultrasonic energy, may be beneficial for fat graft survival. Although TERUS increases the vascularity of fat grafts, it does not improve fat graft survival rates.

No Level Assigned

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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超声波预处理对脂肪移植存活率影响的研究
背景:脂肪移植在整形、重建和美容手术中的应用越来越多。虽然脂肪移植有很多优点,但关于其存活率的证据有限。目前的研究重点是提高脂肪移植的存活率。本研究旨在评估治疗性超声(TERUS)应用对脂肪移植存活的影响。方法:选取成年雄性Wistar Albino大鼠42只,随机分为7组,每组6只:第一组为对照组,仅行脂肪移植;2组术前每日TERUS治疗1周,术后行脂肪移植;3组术前每日推拿1周,术后行脂肪移植术;4组术前每日TERUS治疗1周,术后行脂肪移植及每日TERUS治疗1周;5组术前每日推拿1周,术后行脂肪移植及术后每日推拿1周;6组术后每日接受TERUS治疗1周;第7组术后每日按摩1周。在测量体积和重量后,使用perilipin和PECAM-1进行免疫组织化学评估。采用TUNEL法测定细胞凋亡。结果:两组宏观测量结果无统计学差异。虽然TERUS增加了脂肪移植物的血管化,但它并没有提高存活率。术前-术后推拿组(第5组)脂肪移植体平均存活率显著高于其他各组。结论:本研究结果提示,TERUS的按摩作用不依赖于超声能量,可能有利于脂肪移植物的存活。虽然TERUS增加了脂肪移植物的血管性,但它并不能提高脂肪移植物的存活率。未指定水平:本刊要求作者为每份投稿指定证据水平,以适用循证医学排名。这不包括评论文章、书评和涉及基础科学、动物研究、尸体研究和实验研究的手稿。有关这些循证医学评级的完整描述,请参阅目录或在线作者说明www.springer.com/00266。
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来源期刊
CiteScore
4.40
自引率
25.00%
发文量
479
审稿时长
3 months
期刊介绍: Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP). Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships. Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.
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