Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D₃ supplementation in prediabetes.

IF 3.6 3区医学 Q2 NUTRITION & DIETETICS European Journal of Clinical Nutrition Pub Date : 2025-03-20 DOI:10.1038/s41430-024-01564-z

Peng Ni, Ze Xu, Yujing Zhang, Dongdong Zhang, Hongwei Wen, Yaping Liu, Wenjie Li, Xing Li

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引用次数: 0

Abstract

Background: Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D₃ supplementation responsiveness in prediabetes.

Methods: A total of 240 prediabetic participants received orally 1600 IU of vitamin D₃ or placebo daily for 24 weeks.

Results: CYP2R1 rs12794714 AA carriers had less increased 25(OH)D₃ levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), P = 0.038). Moreover, GC rs4588 GA carriers had less increased 25(OH)D₃ levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), P = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), P = 0.032). GC rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), P = 0.042).

Conclusions: The results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D₃ supplementation responsiveness in prediabetes.

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来源期刊

European Journal of Clinical Nutrition 医学-营养学

CiteScore

10.60

自引率

2.10%

发文量

189

审稿时长

3-6 weeks

期刊介绍： The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)