FPGA-based digitizer for BGO-based time-of-flight PET.

IF 3.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Physics in medicine and biology Pub Date : 2025-03-28 DOI:10.1088/1361-6560/adc362
Daehee Lee, Sun Il Kwon
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Abstract

We present a novel field-programmable gate array (FPGA)-based bismuth germanate (BGO) time-of-flight (TOF) digitizer, implemented on an FPGA (XC7VX485T-2FFG1761C, Xilinx). This digitizer is designed to address the recently highlighted characteristics of BGO, which generates both scintillation and prompt Cerenkov photons when a 511 keV photon interacts with BGO. The developed digitizer independently processes these two types of photons for precise energy and timing measurements. The digitizer incorporates a noise-resistant binary counter that measures energy signals using the time-over-threshold (TOT) method. For timing measurements, we employ an embedded dual-side monitoring time-to-digital converter, which efficiently captures timing information while maintaining low resource usage. We validated the efficacy of our FPGA-based TOF digitizer through extensive experiments, including both electrical testing and coincidence measurements using BGO pixels. Our evaluations of TOT energy and timing performance utilized two 3 × 3 × 20 mm3BGO pixels coupled to CHK-HD MT silicon photomultipliers. The digitizer achieved a coincidence timing resolution (CTR) of 407 ps full width at half maximum (FWHM) for events within the full width at tenth maximum of the photopeak in the measured TOT energy spectrum. Notably, when measured with an oscilloscope, the same detector pair exhibited a CTR of 403 ps FWHM, confirming that the performance of the developed digitizer is comparable to that of an oscilloscope. With its low resource usage, our design offers significant potential for scalability, making it particularly promising for multi-channel BGO-based PET systems.

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基于 FPGA 的数字转换器,用于基于 BGO 的飞行时间 PET。
我们提出了一种基于FPGA的新型锗酸铋(BGO)飞行时间(TOF)数字化仪,在FPGA (XC7VX485T-2FFG1761C, Xilinx)上实现。该数字化仪旨在解决最近突出的BGO特性,当511-keV光子与BGO相互作用时,会产生闪烁和提示切伦科夫光子。开发的数字化仪独立处理这两种类型的光子,以实现精确的能量和时间测量。数字化仪包含一个抗噪声二进制计数器,该计数器使用时间超过阈值(TOT)方法测量能量信号。对于时序测量,我们采用嵌入式双面监控时间-数字转换器,在保持低资源使用的同时有效捕获时序信息。我们通过广泛的实验验证了基于fpga的TOF数字化仪的有效性,包括电气测试和使用BGO像素的一致性测量。我们利用两个3 × 3 × 20 mm3BGO像素耦合到CHK-HD MT硅光电倍增管来评估TOT能量和时序性能。在测量的TOT能谱中,对于光峰值的十分之一全宽度(FWTM)内的事件,数字化仪实现了407 ps的全宽度半最大(FWHM)的重合时序分辨率(CTR)。值得注意的是,当用示波器测量时,相同的检测器对显示出403 ps频宽的CTR,证实了所开发的数字化仪的性能可与示波器相媲美。由于其低资源利用率,我们的设计提供了巨大的可扩展性潜力,使其特别适用于基于bgo的多通道PET系统。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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