{"title":"Design and construction of artificial metabolic pathways for the bioproduction of useful compounds.","authors":"Tomokazu Shirai","doi":"10.5511/plantbiotechnology.24.0721c","DOIUrl":null,"url":null,"abstract":"<p><p>To efficiently produce useful compounds using biological cells, it is essential to optimally design all metabolic reactions and pathways, including not only the flow of carbon within the cell but also the production and consumption of energy and the balance of oxidation-reduction. Computational scientific methods are effective for the rational design of metabolic pathways and the optimization of metabolic fluxes. Based on this blueprint, it is crucial to accurately construct the cell, test and analyze whether it conforms to the design, and learn from the results to redesign the system in an effective cycle. This review introduces essential metabolic design techniques in synthetic biology and discusses the potential of using plant cells or plant genes effectively in synthetic biology for the production of useful compounds.</p>","PeriodicalId":20411,"journal":{"name":"Plant Biotechnology","volume":"41 3","pages":"261-266"},"PeriodicalIF":1.1000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921127/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plant Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.5511/plantbiotechnology.24.0721c","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
To efficiently produce useful compounds using biological cells, it is essential to optimally design all metabolic reactions and pathways, including not only the flow of carbon within the cell but also the production and consumption of energy and the balance of oxidation-reduction. Computational scientific methods are effective for the rational design of metabolic pathways and the optimization of metabolic fluxes. Based on this blueprint, it is crucial to accurately construct the cell, test and analyze whether it conforms to the design, and learn from the results to redesign the system in an effective cycle. This review introduces essential metabolic design techniques in synthetic biology and discusses the potential of using plant cells or plant genes effectively in synthetic biology for the production of useful compounds.
期刊介绍：
Plant Biotechnology is an international, open-access, and online journal, published every three months by the Japanese Society for Plant Biotechnology. The journal, first published in 1984 as the predecessor journal, “Plant Tissue Culture Letters” and became its present form in 1997 when the society name was renamed to Japanese Society for Plant Cell and Molecular Biology, publishes findings in the areas from basic- to application research of plant biotechnology. The aim of Plant Biotechnology is to publish original and high-impact papers, in the most rapid turnaround time for reviewing, on the plant biotechnology including tissue culture, production of specialized metabolites, transgenic technology, and genome editing technology, and also on the related research fields including molecular biology, cell biology, genetics, plant breeding, plant physiology and biochemistry, metabolic engineering, synthetic biology, and bioinformatics.
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