LogODDS as a prognostic factor in oral cavity squamous cell carcinoma

IF 2.4 4区医学 Q3 ONCOLOGY Surgical Oncology-Oxford Pub Date : 2025-03-14 DOI:10.1016/j.suronc.2025.102213

Giada A. Beltramini , Edoardo F. Montrasio , Filippo Da Pozzo , Alessandro Cherchi , Domenico Sfondrini , Andrea Sacconi

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引用次数: 0

Abstract

The objective of the study is to estimate the role of LogODDS as a prognostic factor in patients affected by oral cavity squamous cell carcinoma, in terms of overall survival (OS) and disease-free survival (DFS), looking for a cut-off value that allows to stratify them in high and low risk of recurrency, implementing the informations given by Lymph Node Ratio (LNR) and TNM 8th.

Seventyfour patients affected by oral cavity squamous cell carcinoma with metastatic lymph nodes who have undergone surgery at Maxillofacial Surgery Unit of the Fondazione IRCCS Cà Granda Ospedale Policlinico di Milano, in which a restaging according to TNM 8th was possible and LNR and LogODDS could have been calculated, were enrolled.

Multivariate analysis for OS was statistically relevant for both LogODDS and LNR, where N alone didn't reach the same result. No one of the previous parameters has a statistically relevant meaning in DFS prediction.

LogODDS as a prognostic factor has a statistically compelling meaning in order to predict overall survival in oral squamous cell carcinoma.

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LogODDS作为口腔鳞状细胞癌的预后因素。

该研究的目的是评估LogODDS作为口腔鳞状细胞癌患者的预后因素的作用，在总生存期（OS）和无病生存期（DFS）方面，寻找一个临界值，允许将他们分为高复发风险和低复发风险，实现淋巴结比（LNR）和TNM 8给出的信息。74例口腔鳞状细胞癌伴淋巴结转移的患者在米兰国立高等医院颌面外科接受了手术，其中可以根据TNM 8进行再分期，并且可以计算LNR和LogODDS。OS的多变量分析对于LogODDS和LNR都具有统计学意义，其中单独使用N不能达到相同的结果。上述参数在DFS预测中均不具有统计相关意义。LogODDS作为一种预后因素在预测口腔鳞状细胞癌的总生存率方面具有统计学上令人信服的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.