Van Anh Ta , Caroline Ram-Wolff , Elissa Annabi , Clémentine Chauvel , Adèle de Masson , Marie Beylot-Barry , Jean Soulier , Martine Bagot , Jean-Philippe Vial , Richard Veyrat-Masson , Hélène Moins-Teisserenc
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这些方法虽然稳健，但依赖于高度标准化的程序，其中包括 FC 的所有步骤、事先对健康供体和/或 CTCL 患者的正常 CD4+ T 细胞进行特征描述，以及使用通常只有参考中心才支持的多参数面板要求。在这种情况下，有人提出了利用计算增强数据文件的简化 FC 策略（Seheult 等，2024 年）。然而，SS具有显著的异质性，特别是SC表型的可变性，会随着疾病的进展而不断变化，这突出表明有必要使用更特异的标记物对其进行鉴定。SCs的这种动态特性以免疫表型表达的变化和克隆多样性为特征，为准确诊断和监测带来了挑战，因此在临床实践中应用先进的流式细胞术技术和计算分析至关重要。
期刊介绍：
Journal of Investigative Dermatology (JID) publishes reports describing original research on all aspects of cutaneous biology and skin disease. Topics include biochemistry, biophysics, carcinogenesis, cell regulation, clinical research, development, embryology, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, percutaneous absorption, pharmacology, photobiology, physiology, skin structure, and wound healing
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