Advances in the treatment of autism spectrum disorder: Wharton jelly mesenchymal stem cell transplantation.

World journal of methodology Pub Date : 2025-03-20 DOI:10.5662/wjm.v15.i1.95857

Serdar Kabatas, Erdinç Civelek, Eyüp Can Savrunlu, Umut Karaaslan, Özlem Yıldız, Erdal Karaöz

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Abstract

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multifaceted origins. In recent studies, neuroinflammation and immune dysregulation have come to the forefront in its pathogenesis. There are studies suggesting that stem cell therapy may be effective in the treatment of ASD.

Aim: To evolve the landscape of ASD treatment, focusing on the potential benefits and safety of stem cell transplantation.

Methods: A detailed case report is presented, displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) transplantation combined with neurorehabilitation.

Results: The study demonstrates a significant improvement in the child's functional outcomes (Childhood Autism Rating Scale, Denver 2 Developmental Screening Test), especially in language and gross motor skills. No serious side effects were encountered during the 2-year follow-up.

Conclusion: The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

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自闭症谱系障碍的治疗进展：华顿果冻间充质干细胞移植。

背景：自闭症谱系障碍（ASD）是一种复杂的神经发育障碍，具有多方面的起源。在最近的研究中，神经炎症和免疫失调已成为其发病机制的前沿。有研究表明，干细胞疗法可能对ASD的治疗有效。目的：发展ASD治疗的前景，重点关注干细胞移植的潜在益处和安全性。方法：一份详细的病例报告，展示了一名接受鞘内和静脉Wharton’s果冻源间充质干细胞（WJ-MSCs）移植联合神经康复治疗的儿童的积极结果。结果：该研究表明，在儿童的功能结果（儿童自闭症评定量表，丹佛2发育筛选测试），特别是在语言和大运动技能显著改善。在2年的随访中未发现严重的副作用。结论：研究结果支持WJ-MSC移植治疗ASD的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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World journal of methodology

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