Cocooning Wound for Healing

IF 9.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nano Letters Pub Date : 2025-03-21 DOI:10.1021/acs.nanolett.5c00575

Kaisong Huang, Renjie Tan, Hanbai Wu, Yifan Si, Leqi Lei, Hanyue Lan, Chi-wai Kan, Wenjie Fang, Shuai Zhang, Ke Zhang and Jinlian Hu*,

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Abstract

Wound healing is highly sensitive to environmental conditions. Under solar radiation, elevated wound temperatures and UV-rays can induce oxidative stress, disrupt the wound environment, provoke inflammation, and even cause thermal injury. Lower wound temperatures may hinder angiogenesis and immune function, thus delaying recovery. Inspired by silkworm cocooning for thermal comfort during metamorphosis, we developed the wound cocoon (W-cocoon) using a portable high-speed electro-blow spinning (EBS) device. The W-cocoon integrates radiative cooling and thermal insulation properties, providing both cooling (3.9 °C) under sunlight and warming (1.9 °C) indoors. Based on animal studies, the W-cocoon promotes wound recovery in indoor scenarios, while under solar radiation, its high reflectivity and UV-blocking ratio mitigate the negative effects of radiation, thus optimizing wound healing. Additionally, the W-cocoon exhibits superhydrophobic and hemophobic properties, which endow the dressing with antifouling capabilities and reduce pain during dressing changes.

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茧状伤口愈合

伤口愈合对环境条件非常敏感。在太阳辐射下，伤口温度升高和紫外线可引起氧化应激，破坏伤口环境，引发炎症，甚至引起热损伤。较低的伤口温度可能会阻碍血管生成和免疫功能，从而延迟恢复。灵感来自于蚕在变态过程中的热舒适茧，我们开发了一种使用便携式高速电吹纺丝（EBS）设备的伤口茧（W-cocoon）。W-cocoon集辐射冷却和隔热性能于一体，在日光下提供冷却（3.9℃），在室内提供加热（1.9℃）。动物实验表明，在室内环境下，w -茧能促进伤口恢复，而在太阳辐射下，w -茧的高反射率和紫外线阻隔率减轻了辐射的负面影响，从而优化伤口愈合。此外，w -茧表现出超疏水和疏血特性，这赋予敷料防污能力，减少敷料更换时的疼痛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.