Prognostic outcomes and influencing factors of peritoneal dialysis-related peritonitis: A retrospective single-center study.

Abstract

Background: This study aims to elucidate the determinants contributing to the onset of peritonitis in individuals undergoing peritoneal dialysis (PD), thereby establishing a clinical foundation for diminishing the prevalence of PD-associated peritonitis.

Materials and methods: A retrospective examination was conducted on the clinical records of 485 cases diagnosed with PD peritonitis at the General Hospital of Ningxia Medical University over a decade (2010 - 2020). Data scrutinized included demographic details, underlying diseases, duration of dialysis, etiology of infection, economic background, predisposing factors, and bacterial pathogens.

Results: The analysis identified surgical or gynecological interventions and gastrointestinal infections from contaminated food as predominant precursors to PD-related peritonitis. Prognostically, patients with gastrointestinal infections linked to contaminated food intake and those with viral afflictions fared worse compared to their counterparts in the recovery cohort. The principal infectious agents were identified as Gram-positive cocci. Notable disparities in gender, duration of dialysis treatment, and antecedent peritonitis episodes were observed between those who recovered and those who did not. Binary logistic regression pinpointed extended duration of dialysis and bacterial etiology as independent prognostic indicators for adverse outcomes in PD peritonitis patients.

Conclusion: The study concludes that both protracted dialysis treatment and bacterial etiology serve as independent prognostic determinants for PD-related peritonitis outcomes.