Glucocorticoids, Concomitant Immunosuppression, and PJP Prophylaxis Among U.S. Adults.

IF 8.2 1区 医学 Q1 IMMUNOLOGY Clinical Infectious Diseases Pub Date : 2025-03-21 DOI:10.1093/cid/ciaf147
Daniel B Chastain, George R Thompson, Andrés F Henao-Martínez
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Abstract

The impact of glucocorticoids, comorbidities, and immunosuppressive therapies on Pneumocystis jirovecii pneumonia (PJP) risk remains understudied, and prophylaxis is underutilized. Among U.S. adults in TriNetX prescribed glucocorticoids for ≥2 weeks in TriNetX, 44.6% received >20mg prednisone equivalents/day. Prophylaxis rates were low, with higher glucocorticoid doses associated with lower prophylaxis odds.

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糖皮质激素,伴随免疫抑制和PJP预防在美国成年人。
糖皮质激素、合并症和免疫抑制疗法对耶氏肺囊虫肺炎(PJP)风险的影响仍未得到充分研究,预防措施也未得到充分利用。在服用TriNetX的美国成年人中,服用糖皮质激素≥2周的TriNetX中,44.6%的人接受了100 - 20mg强的松当量/天。预防率低,较高的糖皮质激素剂量与较低的预防几率相关。
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来源期刊
Clinical Infectious Diseases
Clinical Infectious Diseases 医学-传染病学
CiteScore
25.00
自引率
2.50%
发文量
900
审稿时长
3 months
期刊介绍: Clinical Infectious Diseases (CID) is dedicated to publishing original research, reviews, guidelines, and perspectives with the potential to reshape clinical practice, providing clinicians with valuable insights for patient care. CID comprehensively addresses the clinical presentation, diagnosis, treatment, and prevention of a wide spectrum of infectious diseases. The journal places a high priority on the assessment of current and innovative treatments, microbiology, immunology, and policies, ensuring relevance to patient care in its commitment to advancing the field of infectious diseases.
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