A 1-year review of anti-Ro/La autoantibody testing in an obstetric population.

IF 1.6 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Irish Journal of Medical Science Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI:10.1007/s11845-025-03935-2
Elizabeth Tunney, Clare M Crowley, Claire M McCarthy, Etaoin Kent
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Abstract

Objectives: To evaluate current anti-Ro and anti-La autoantibody ordering patterns, clinical indications for performing these tests, and potential cost-benefit analysis.

Methods: In this retrospective cohort study, patients who underwent autoantibody testing over 1 year were included. Necessary information was obtained from patient electronic records.

Results: In total 47 patients underwent anti-Ro/La autoantibody testing. Of those tested, 11/47 (2%) had positive results and testing was clinically indicated in 26/47 (55%) patients, indicating minimal cost-benefits. The total rate of the cost prescription was €1644.96. The mean time to process tests was 5 days. In those with positive autoantibodies, two infants were diagnosed with congenital heart block and had pacemakers inserted after delivery.

Conclusion: This study found anti-Ro/La autoantibody tests were appropriately ordered in accordance with clinical guidelines. By identifying patients who were autoantibody negative, economic benefits were gained, in terms of antenatal management including reduced frequency of antenatal visits and fetal heart surveillance.

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产科人群抗ro /La自身抗体检测的1年回顾
目的:评估当前抗ro和抗la自身抗体的排序模式,进行这些测试的临床适应症,以及潜在的成本效益分析。方法:在这项回顾性队列研究中,纳入了接受1年以上自身抗体检测的患者。从病人的电子记录中获得必要的信息。结果:47例患者接受了抗ro /La自身抗体检测。在接受检测的患者中,11/47(2%)的结果呈阳性,26/47(55%)的患者临床需要进行检测,这表明成本效益最低。费用处方总费率为1644.96欧元。处理测试的平均时间为5天。在那些自身抗体阳性的婴儿中,有两名婴儿被诊断为先天性心脏传导阻滞,并在分娩后植入了起搏器。结论:本研究发现抗ro /La自身抗体检测是按照临床指南进行的。通过识别自身抗体阴性的患者,在产前管理方面获得了经济效益,包括减少产前就诊频率和胎儿心脏监测。
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来源期刊
Irish Journal of Medical Science
Irish Journal of Medical Science 医学-医学:内科
CiteScore
3.70
自引率
4.80%
发文量
357
审稿时长
4-8 weeks
期刊介绍: The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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