Traditional Herbal Medicine Pithecellobium clypearia (Jack) Benth: Research progress in chemical constituents and pharmacological activities

Abstract

Ethnopharmacological relevance

Pithecellobium clypearia, a traditional herbal medicine, has garnered widespread attention for its significant anti-infective benefits. However, there is currently a lack of comprehensive reviews examining the chemical constituents and pharmacological activities of P. clypearia.

Aims of the study

This review aims to investigate the chemical constituents and pharmacological effects of P. clypearia, and to explore its potential for wider medical applications through the synthesis of these findings.

Materials and methods

The Web of Science, PubMed, CNKI, Google Scholar, and WanFang databases were searched for Pithecellobium clypearia, Using “Pithecellobium clypearia”, “Archidendron clypearia”, “pharmacology”, “chemical composition” and “biological activity”, as the keywords, we summarized the main chemical compositions and pathological mechanisms of P. clypearia.

Results

A total of 129 compounds were isolated from P. clypearia, the primary active components identified include flavonoids, polysaccharides, lignins, triterpenoids, steroids, and phenolic acids. These compounds contribute to the medicinal plant's diverse pharmacological effects, which include antiviral, antibacterial, anti-inflammatory, antioxidant, and neuroprotective properties. P. clypearia presents great potential, especially in its antiviral and anti-inflammatory effects, indicating its valuable role in future therapeutic strategies.

Conclusion

P. clypearia has demonstrated effectiveness and safety in treating various respiratory and gastrointestinal diseases. It shows good monotherapy efficacy and significantly enhances overall treatment outcomes when used in combination therapy. P. clypearia is a valuable treatment option for patients of different age groups and provides a safe and effective alternative in various clinical settings.