Enhancement of the dosimetric properties of N-vinyl caprolactam polymer gel dosimeter for clinical practice

IF 1.8 3区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Applied Radiation and Isotopes Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI:10.1016/j.apradiso.2025.111796
Khalid A. Rabaeh , Molham M. Eyadeh , Ahmad J.A. Alrub
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Abstract

In this study, the impact of Lithium Chloride inorganic salt sensitizer on the performance of N-vinyl caprolactam polymer-gel dosimeter was evaluated in terms of dose-response combined with spin-spin relaxation rate (R2) obtained from nuclear magnetic resonance relaxometry technique. The irradiation experiments were conducted using a medical linear accelerator, and the improved polymer gel dosimeters were exposed to various doses, photon beam energies, and dose rates. The signal development of the dosimeters was analyzed using a 0.5 T nuclear magnetic resonance instrument. The dose response of the improved gel at different concentration of co-monomers and at different types of gelatins was investigated. Results showed that the R2 sensitivity of the dosimeter was improved with an increase in Lithium Chloride concentration. With 6 % Lithium Chloride, the sensitivity was improved by more than one and half to two times in the linear dose response rang of (0–10 Gy). Furthermore, no significant impact was seen from varying dose rates and photon energy with the improved dosimeter, and R2 was not affected by changing the irradiation temperature from 10 to 30 °C. Additionally, the dose-response and hence R2 data decreased with increasing scanning temperature and the response was stable for up to five days after irradiation. The polymer gel dosimetry accuracy was estimated by calculating the overall uncertainty and found to be 4.06 % (2σ, 95 % confidence level).
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提高n -乙烯基己内酰胺聚合物凝胶剂量计的临床应用剂量学性能
本研究利用核磁共振弛豫技术得到的自旋-自旋弛豫速率(R2),结合剂量-响应,评价了氯化锂无机盐增敏剂对n-乙烯基己内酰胺聚合物-凝胶剂量计性能的影响。利用医用直线加速器进行辐照实验,对改进后的聚合物凝胶剂量计进行了不同剂量、光子束流能量和剂量率的辐照试验。采用0.5 T核磁共振仪对剂量计的信号发展进行了分析。考察了改进后的凝胶在不同浓度的共单体和不同类型的明胶下的剂量反应。结果表明,该剂量计的R2灵敏度随氯化锂浓度的增加而提高。在(0 ~ 10 Gy)的线性剂量响应范围内,6%氯化锂的灵敏度提高了1.5 ~ 2倍以上。此外,在改进的剂量计中,不同的剂量率和光子能量对R2没有显著影响,并且将辐照温度从10°C改变为30°C对R2没有影响。此外,剂量响应和R2数据随扫描温度的升高而降低,并且在辐照后5天内响应保持稳定。通过计算总体不确定度估算聚合物凝胶剂量测定的准确度为4.06% (2σ, 95%置信水平)。
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来源期刊
Applied Radiation and Isotopes
Applied Radiation and Isotopes 工程技术-核科学技术
CiteScore
3.00
自引率
12.50%
发文量
406
审稿时长
13.5 months
期刊介绍: Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.
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