3-Fluorooxindoles from indolin-2-ones by Selectfluor

IF 2.2 3区 化学 Q2 CHEMISTRY, ORGANIC Tetrahedron Pub Date : 2025-06-01 Epub Date: 2025-02-26 DOI:10.1016/j.tet.2025.134556
Hui Qin , Guo-Liang Wei , Fu-Wei Wang , Xiao-Hong Mao , Mei-Hua Bao , Yi-Wen Zhang , Ping Huang , Xiao-Wei Zheng
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Abstract

Herein, a practical and efficient method for fluorinating various indolin-2-ones under mild conditions was presented, utilizing selectfluor as a cost-effective fluorination reagent. Notably, the protocol operated under environmentally friendly conditions, facilitating the generation of various substituted indolin-2-ones into corresponding fluorinated indolin-2-ones in moderate to good yields, all without the need for an alkali source or heating.

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Selectfluor从吲哚-2- 1中提取3-氟辛孔
本文利用选择性氟作为一种经济高效的氟化试剂,提出了一种在温和条件下对多种吲哚-2- 1进行氟化的方法。值得注意的是,该议定书是在环境友好的条件下进行的,有助于以中等至较高的产量将各种取代的吲哚-2- 1生成相应的氟化吲哚-2- 1,所有这些都不需要碱源或加热。
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来源期刊
Tetrahedron
Tetrahedron 化学-有机化学
CiteScore
3.90
自引率
4.80%
发文量
439
审稿时长
34 days
期刊介绍: Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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