Dual-functionality of Hibiscus sabdariffa-CuO nanoparticles in chemotherapy and textile screen-printing on cellulose-based textiles

IF 4.8 2区工程技术 Q1 MATERIALS SCIENCE, PAPER & WOOD Cellulose Pub Date : 2025-02-11 DOI:10.1007/s10570-025-06429-7

Elif Tüzün, Ayşe Erol, Ferdane Danışman Kalındemirtaş, Fatih Özbaş, Esra Sert, Razium Ali Soomro, Ayman Nafady, Selcan Karakuş

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Abstract

The dual-functional nanostructures show great promise for biomedical applications, exhibiting selective cytotoxicity against cancer cells while also serving as a crucial component in textile screen-printing for smart materials. In this study, we successfully synthesized polyethylene glycol-hibiscus extract copper (II) oxide nanoparticles (PEG/HS/CuO NPs) using a simple one-step sonosynthesis method that leverages ultrasonic irradiation. Comprehensive characterization of the synthesized PEG/HS/CuO NPs was performed using transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM) coupled with energy-dispersive X-ray (EDX) analysis, and Fourier-transform infrared spectroscopy (FTIR). The incorporation of PEG/HS/CuO NPs into guar gum photochromic solution (GP) caused a significant color change after 6 ± 1 min of UV light exposure and resulted in visible coloration on cellulose-based textiles after screen printing, providing an alternative strategy for smart fabrics. Moreover, cytotoxicity experiments demonstrated the selective toxicity of green PEG/HS/CuO NPs against cancer cells. In this study, the human colon cancer cell line HCT116, breast cancer cell line MCF-7, and normal HUVEC cells were examined. PEG/HS/CuO NPs NPs induced apoptosis, cell cycle arrest, and down-regulation of CD44 antibody expression in MCF-7 cells, highlighting their potential as effective chemotherapy agents.

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木槿cuo纳米颗粒在化疗和纤维素基纺织品丝网印刷中的双重功能

双功能纳米结构在生物医学应用方面显示出巨大的前景，表现出对癌细胞的选择性细胞毒性，同时也作为智能材料丝网印刷的关键组成部分。在这项研究中，我们成功地利用超声辐照的简单一步超声合成方法合成了聚乙二醇-芙蓉提取物氧化铜纳米粒子（PEG/HS/CuO NPs）。利用透射电子显微镜（TEM）、x射线衍射（XRD）、扫描电子显微镜（SEM）和能量色散x射线（EDX）分析以及傅里叶变换红外光谱（FTIR）对合成的PEG/HS/CuO纳米粒子进行了综合表征。将PEG/HS/CuO NPs加入瓜尔胶光致变色溶液（GP）中，在紫外线照射6±1分钟后，纤维基纺织品的颜色发生了显著变化，并在丝网印刷后产生了可见的颜色，为智能织物提供了另一种策略。此外，细胞毒性实验表明，绿色PEG/HS/CuO NPs对癌细胞具有选择性毒性。本研究对人结肠癌细胞系HCT116、乳腺癌细胞系MCF-7和正常HUVEC细胞进行了检测。PEG/HS/CuO NPs NPs在MCF-7细胞中诱导凋亡、细胞周期阻滞和CD44抗体表达下调，突出了它们作为有效化疗药物的潜力。

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来源期刊

Cellulose 工程技术-材料科学：纺织

CiteScore

10.10

自引率

10.50%

发文量

580

审稿时长

3-8 weeks

期刊介绍： Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.