Dae-Cheol Choi , Yoon Hee Kim , Min-Ju Park , Da Young Hwang , Ji-Yul Kim , Yeong-Seon Won , In-Kyoung Lee , Dae-Won Ki , Bong-Sik Yun
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引用次数: 0
Abstract
Two new compounds, a benzofuran derivative (1) and a benzoate derivative (2), along with four known γ-pyrones (3–6), were isolated from the culture broth of Dentipellis fragilis. Their chemical structures were elucidated via spectroscopic analysis. The anti-inflammatory and cytotoxic effects of these compounds were assessed. Compound 4 exhibited significant anti-inflammatory activity, inhibiting approximately 60 % of NO production at 0.005 μM without cytotoxic effects. Additionally, compound 2 showed moderate cytotoxicity against HCT-116 and Mia Paca-2 human cancer cells, with IC50 values.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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