lncRNA GAS 5 rs145204276 as a risk factor for primary immune thrombocytopenia in the Chinese Han population.

IF 2.1 4区医学 Q2 HEMATOLOGY Expert Review of Hematology Pub Date : 2025-01-01 Epub Date: 2025-03-25 DOI:10.1080/17474086.2025.2483669

Ting Liang, Hong Yi, Huanyu Guo, Yingjie Xie, Jianhua Hu, Yongchun Chen

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Abstract

Background: Recent studies suggest that long noncoding RNA (lncRNA) GAS 5 plays a crucial role in the pathogenesis of primary immune thrombocytopenia (ITP). Identification of genetic variations affecting GAS 5 expression may provide insights into ITP mechanisms. This study aimed to explore the association between GAS 5 variants rs145204276 andrs55829688 and ITP risk in a Chinese Han population.

Research design and methods: The genotypes of rs145204276 and rs55829688 were analyzed in 302 ITP patients and 300 age-matched healthy controls. GAS 5 expression levels were quantified using quantitative real-time PCR (qRT-PCR) in both groups.

Results: Significant differences in allele and genotype frequencies of rs145204276 were observed between ITPpatients and healthy controls. Specifically, the deletion allele of rs145204276 was associated with a reduced risk of ITP and higher GAS 5 expression inpatients. However, no significant association was found for rs55829688 in any analysis.

Conclusions: The rs145204276polymorphism in GAS 5 is significantly associated with ITP susceptibility and may serve as a potential biomarker for ITP prevention and treatment.

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lncRNA GAS 5 rs145204276是中国汉族人群原发性免疫性血小板减少症的风险因素。

背景：最近的研究表明，长链非编码RNA (lncRNA) gas5在原发性免疫性血小板减少症（ITP）的发病机制中起着至关重要的作用。鉴定影响gas5表达的遗传变异可能有助于深入了解ITP的机制。本研究旨在探讨中国汉族人群中gas5变异rs145204276和rs55829688与ITP风险之间的关系。研究设计与方法：分析302例ITP患者和300例年龄匹配的健康对照者的rs145204276和rs55829688基因型。采用实时荧光定量PCR （qRT-PCR）检测两组细胞中gas5的表达水平。结果：it患者与健康对照在rs145204276等位基因和基因型频率上存在显著差异。具体来说，缺失rs145204276等位基因与ITP风险降低和住院患者gas5表达升高相关。然而，在任何分析中均未发现rs55829688的显著相关性。结论：gas5基因rs145204276多态性与ITP易感性显著相关，可能作为ITP预防和治疗的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.