Human papillomavirus genotype distribution among high-grade cervical lesions in French women born between 1972 and 1993

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY Journal of gynecology obstetrics and human reproduction Pub Date : 2025-03-21 DOI:10.1016/j.jogoh.2025.102945

Philomène Lenoir , Julie Guillet , Maxime Desmarets , Alice Baraquin , Rajeev Ramanah , Justine Rousse , Christiane Mougin , Quentin Lepiller , Jean-Luc Prétet , HPV Impact Study Group

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Abstract

Background

Implementation of HPV vaccination programmes may induce significant changes in the distribution of HPV genotypes detected in cervical (pre-)cancers.

Methods

In a multicentre study in France, we investigated the distribution of HPV genotypes using a sensitive molecular technique in 611 histological specimens diagnosed with high-grade lesions (CIN2/3) in a large cohort of women born between 1972 and 1993. Women born after 1983 were potentially vaccinated because of their young age.

Results

High-risk HPV genotypes were detected in 93.4 % of women and 24.4 % had a multiple infections. HPV16/18 genotypes were more frequently associated with CIN3 than with CIN2 lesions (66 % vs. 57 %, p = 0.045). The prevalence of HPV16 and HV18 genotypes did not change according to the year of birth.

Conclusion

Contrary to previous descriptions in countries with a high HPV vaccination coverage, we did not observe difference in the prevalence of HPV16 and HPV18 genotypes in CIN2/3 lesions after the introduction of HPV vaccination in France, in a context of low national vaccination coverage.

ClinicalTrials.gov ID

NCT04167501

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人乳头瘤病毒基因型分布在1972年至1993年出生的法国妇女高度宫颈病变。

背景：实施HPV疫苗接种计划可能会导致宫颈癌（前）癌中检测到的HPV基因型分布发生重大变化。方法：在法国的一项多中心研究中，我们使用敏感分子技术调查了1972年至1993年间出生的妇女中611例诊断为高级别病变（CIN2/3）的组织学标本的HPV基因型分布。1983年以后出生的女性由于年龄小，有可能接种疫苗。结果：93.4%的妇女检出高危HPV基因型，24.4%的妇女有多发感染。HPV16/18基因型与CIN3病变的相关性高于与CIN2病变的相关性（66%比57%，p=0.045）。HPV16和HV18基因型的患病率不随出生年份的变化而变化。结论：与之前在HPV疫苗接种覆盖率高的国家的描述相反，在法国引入HPV疫苗接种后，在全国疫苗接种覆盖率低的背景下，我们没有观察到HPV16和HPV18基因型在CIN2/3病变中的患病率差异。临床试验：政府编号：NCT04167501。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of gynecology obstetrics and human reproduction Medicine-Obstetrics and Gynecology

CiteScore

3.70

自引率

5.30%

发文量

210

审稿时长

31 days

期刊介绍： Formerly known as Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Journal of Gynecology Obstetrics and Human Reproduction is the official Academic publication of the French College of Obstetricians and Gynecologists (Collège National des Gynécologues et Obstétriciens Français / CNGOF). J Gynecol Obstet Hum Reprod publishes monthly, in English, research papers and techniques in the fields of Gynecology, Obstetrics, Neonatology and Human Reproduction: (guest) editorials, original articles, reviews, updates, technical notes, case reports, letters to the editor and guidelines. Original works include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses.