Application of RNA sequencing in urologic malignancies: Advances and challenges

Abstract

RNA sequencing became a key tool in identifying the differences between cells and their functions, aiding in the recognition of the functional elements disrupted during the disease process. In urologic malignancies, many studies aiming to provide comprehensive molecular classifications through the assessment of RNA expression or fusion analysis have been published. The distinctive presence of these molecular alterations related to cancer development, growth, and survival and the discoveries of these breakthrough studies provide insight into the development of personalized management and aid in the identification of new therapeutic targets.