Naoki Oku, Reo Saeki, Yuriko Doi, Ken Yamazaki, Tomoya Miura
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引用次数: 0
Abstract
We report herein a photoinduced nickel-catalyzed 1,2-acylcyanation of styrenes with acyl fluorides and trimethylsilyl cyanide (TMSCN). Nickel(II) acyl complexes, formed from nickel(0) complexes and acyl fluorides, are photoexcited to generate acyl radicals via a ligand-to-metal charge transfer (LMCT) process. This transformation proceeds under mild conditions and thus can be applied to the late-stage functionalization (LSF) of natural product derivatives. Synthetic derivatizations show the utility of the products. The preparation of aza-DIPYs is also demonstrated.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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