Electroencephalographic responses before, during, and after upper limb paired associative stimulation

Abstract

Paired associative stimulation (PAS) is a non-invasive protocol involving repeated stimulus pairs to activate two cortical areas alternately, inducing Hebbian-like plasticity. However, its neurophysiological impacts remain unclear. To determine the changes that occur in the brain during PAS, brain activity during PAS must be measured and distinguished from the electromagnetic artifacts produced by the stimulation. Here, we present a novel dataset of electroencephalography (EEG) measurements during PAS with an inter-stimulus-interval of 25 ms (PAS₂₅, expected to induce long-term potentiation-like changes) or 35 ms (PAS₃₅, no expected change). This dataset includes raw data and pre-processed data with electromagnetic artefacts removed. The right ulnar nerve's electrical stimulation preceded transcranial magnetic stimulation to the left primary motor cortex in both cases. EEG was measured before and after the PAS sessions, with only electrical or magnetic stimulation. To demonstrate the quality of the data, we summarize the stability of the stimulation site and the event-related potentials before, during, and after PAS. This dataset will enable observing brain dynamics due to the accumulation of stimulations during PAS and differences in responsiveness to stimulations before and after PAS.