The art of decorating piperidine scaffold into alkaloid precursors

Abstract

The piperidine scaffold is probably the non-carbocyclic system with the highest presence in both natural and designed alkaloids. For this reason, chemists have visualized the opportunity for designing tactics and strategies to functionalize their unreactive C(sp³)−H bonds into key alkaloid precursors, which eventually ends up in the total synthesis of very important bioactive compounds. Accordingly, the current review accounts, in an organized two forms, the way of how chemist “decorate” specific positions of the piperidine ring either by mediated transition-metal catalyzed (TMC) reactions or under transition-metal-free (TMF) conditions.