{"title":"Bacteria-Responsive Drug Delivery System Utilizing Carboxymethyl Cellulose-Functionalized Metal-Organic Framework for Enhanced Antibacterial Efficacy.","authors":"Pingping Yuan, Mengying Zhang, Sheng Wang, Lin Li, Runan Zuo, Shaoqi Qu","doi":"10.1021/acsbiomaterials.5c00084","DOIUrl":null,"url":null,"abstract":"<p><p>Bacterial infections pose a significant threat to human health and economic stability. The overuse of antibiotics has exacerbated bacterial resistance, highlighting the urgent need for innovative strategies to combat this issue. Bacteria-responsive drug delivery systems present a promising solution to overcoming bacterial resistance. Metal-organic frameworks (MOFs), versatile porous materials created by linking metal clusters with organic ligands, are ideal candidates for such applications. Here, we employed the zeolite imidazole framework 8 (ZIF-8) as a carrier for ceftiofur (EFT), enhanced with carboxymethyl cellulose to develop a smart drug delivery system (CMC-EFT@ZIF-8) responsive to pH and cellulase. <i>In vitro</i> tests demonstrated that this system released a higher quantity of EFT under acidic conditions and in the presence of cellulase, leading to more effective disruption of bacterial membranes and subsequent bacterial death. The CMC-EFT@ZIF-8 system achieved a 99% clearance of <i>Pseudomonas aeruginosa</i> within 6 h and showed superior efficacy in a mouse skin wound model. These findings underscore the potential of our smart drug delivery system to significantly improve treatment outcomes for bacterial infections, representing a significant advancement in the fight against antibiotic resistance.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"2216-2225"},"PeriodicalIF":5.5000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.5c00084","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Bacterial infections pose a significant threat to human health and economic stability. The overuse of antibiotics has exacerbated bacterial resistance, highlighting the urgent need for innovative strategies to combat this issue. Bacteria-responsive drug delivery systems present a promising solution to overcoming bacterial resistance. Metal-organic frameworks (MOFs), versatile porous materials created by linking metal clusters with organic ligands, are ideal candidates for such applications. Here, we employed the zeolite imidazole framework 8 (ZIF-8) as a carrier for ceftiofur (EFT), enhanced with carboxymethyl cellulose to develop a smart drug delivery system (CMC-EFT@ZIF-8) responsive to pH and cellulase. In vitro tests demonstrated that this system released a higher quantity of EFT under acidic conditions and in the presence of cellulase, leading to more effective disruption of bacterial membranes and subsequent bacterial death. The CMC-EFT@ZIF-8 system achieved a 99% clearance of Pseudomonas aeruginosa within 6 h and showed superior efficacy in a mouse skin wound model. These findings underscore the potential of our smart drug delivery system to significantly improve treatment outcomes for bacterial infections, representing a significant advancement in the fight against antibiotic resistance.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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