Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey
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引用次数: 0
Abstract
Background: Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection.
Methods: Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines.
Results: Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001).
Conclusions: Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.
期刊介绍：
Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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