Design, Development and Evaluation of Polyherbal Lollipops Formulation for the Treatment of Oral Thrush and Periodontal Disease

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY Journal of Pharmaceutical Innovation Pub Date : 2025-03-26 DOI:10.1007/s12247-025-09970-x

Rushikesh Kshirsagar, Varsha Balkrishna Mane, Nagesh Aloorkar, Divya Bhagat, Sanuja Kadam, Sagar Pathade

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Abstract

Purpose

The present investigation aims to formulate a polyherbal lollipops incorporating Neem (Azadirachta indica), Clove (Syzygium aromaticum), Ginger (Zingiber officinale) extract to combat dental problems of Oral Thrush and Periodontal Disease.

Methods

Such lollipops were successfully prepared by using heating and congealing method using 23 full factorial design approach. Sucrose, Methyl Cellulose and corn syrup were considered as independent variables and their effect was studied on Hardness, drug release and disintegration time considering as a dependent variable.

Result

The optimized formulation was found to be symmetrical, smooth, and clear with shiny surfaces and no inconsistencies. The hardness and disintegration time of formulation with increasing concentration ranges between 6 (Kg/cm.sq) -14 (Kg/cm.sq) and 7.56 min to 14.11 min. whereas the drug release was found in between 25.34 ± 2.3% to 89.01 ± 1.9%. After evaluating formulation it has been found that level of independent variables positively affects the Hardness and disintegration time while negatively affects drug release.

Conclusion

The formulation showed enhanced antifungal (candida albicans) and anti-bacterial (streptococcus mutans) activities when compared with standard drugs of Ketoconazole and Erythromycin respectively.

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治疗鹅口疮和牙周病的复方棒棒糖制剂的设计、研制与评价

目的研制一种含有印楝、丁香、姜提取物的多药棒棒糖，用于治疗鹅口疮和牙周病。方法采用23全因子设计方法，采用加热凝固法制备该棒棒糖。以蔗糖、甲基纤维素和玉米糖浆为自变量，以其硬度、释药量和崩解时间为因变量，研究其对崩解时间的影响。结果优化后的配方均匀、光滑、清晰，表面有光泽，无不一致现象。随着浓度的增加，制剂的硬度和崩解时间在6 (Kg/cm.sq) ~ 14 （Kg/cm.sq）和7.56 ~ 14.11 min之间，释放度在25.34±2.3% ~ 89.01±1.9%之间。通过对制剂的评价，发现自变量水平对硬度和崩解时间有正向影响，对药物释放有负向影响。结论与标准药酮康唑和红霉素相比，该制剂具有较强的抗真菌（白色念珠菌）和抗细菌（变形链球菌）活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.