Pediatric CNS Radiation Oncology: Recent Developments and Novel Techniques.

IF 3.4 4区 医学 Q2 ONCOLOGY Current oncology Pub Date : 2025-03-20 DOI:10.3390/curroncol32030180
Justin Oh, Samir Patel, Mary-Pat Schlosser, Andrew J Arifin, Carol Oliveira, Anne-Marie Charpentier, Derek S Tsang
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Abstract

Radiation therapy (RT) is a cornerstone in the management of pediatric central nervous system (CNS) tumors. Recent advancements in RT delivery and techniques aim to enhance therapeutic effectiveness while minimizing both acute and long-term complications associated with pediatric brain RT. This paper highlights innovative developments in the field, including the clinical indications, benefits, and challenges of proton therapy and stereotactic radiotherapy. The ongoing refinement of risk-adapted RT volumes is highlighted, with examples of newly proposed germinoma RT volumes and hippocampal-sparing RT. Additionally, emerging experimental approaches, including FLASH therapy and theranostics, are also discussed as promising future directions. Further prospective, multi-institutional collaborative studies are essential to validate and expand upon the benefits outlined in this review.

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儿童中枢神经系统放射肿瘤学:最新发展和新技术。
放射治疗(RT)是治疗小儿中枢神经系统(CNS)肿瘤的基石。放射治疗给药和技术的最新进展旨在提高治疗效果,同时最大限度地减少与小儿脑部放射治疗相关的急性和长期并发症。本文重点介绍了该领域的创新发展,包括质子治疗和立体定向放射治疗的临床适应症、优势和挑战。本文重点介绍了风险适应性 RT 容量的不断完善,并举例说明了新提出的生殖细胞瘤 RT 容量和海马区保留 RT。此外,还讨论了新出现的实验方法,包括FLASH疗法和治疗学,这些都是很有希望的未来发展方向。进一步的前瞻性多机构合作研究对于验证和扩大本综述中概述的益处至关重要。
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来源期刊
Current oncology
Current oncology ONCOLOGY-
CiteScore
3.30
自引率
7.70%
发文量
664
审稿时长
1 months
期刊介绍: Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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