Stefania Tuveri, Nathalie Brison, Tatjana Jatsenko, Barbara Dewaele, Cindy Melotte, Charlotte Maggen, Vincent Vandecaveye, Peter Vandenberghe, Frederic Amant, Liesbeth Lenaerts, Joris R Vermeesch
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引用次数: 0
Abstract
Genome-wide plasma cfDNA pan-cancer screening of 1002 healthy elderly identified 15 individuals with CNAs of unknown origin. Nine participants were reassessed over 3-5 years through health questionnaires, WB-MRI, and cfDNA and blood analyses. CNAs resolved in two cases but persisted in seven mainly associated with low-grade clonal mosaicism. These findings suggest cfDNA CNAs may be transient or serve as early markers of clonal mosaicism, preceding clinical detection by years.
期刊介绍：
Online-only and open access, npj Precision Oncology is an international, peer-reviewed journal dedicated to showcasing cutting-edge scientific research in all facets of precision oncology, spanning from fundamental science to translational applications and clinical medicine.
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