The Validation Of COVID-19 Information In The Pharmacoepidemiological Research Database of Spain's Public Health System Data by Vaccination Status.

Oliver Astasio, Belén Castillo-Cano, Beatriz Sánchez Delgado, Fabio Riefolo, Rosa Gini, Elisa Martín-Merino
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Abstract

Purpose: To validate COVID-19 information records in The Pharmacoepidemiological Research Database for Public Health System (BIFAP) of Spain.

Methods: The recorded COVID-19 cases in primary care or positive test registries (gold-standard) were identified among vaccinated patients against COVID-19 infection and their matched unvaccinated controls, between December 2020 and October 2021. The sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were estimated for primary care records.

Results: Among 21,702 patients with positive tests and 20,866 with recorded COVID-19 diagnoses, the sensitivity, specificity, PPV and NPV were, respectively, 79.98 percent, 99.95 percent, 80.24 percent, and 99.94 percent among vaccinated, and 78.67 percent, 99.96 percent, 84.51 percent and 99.94 percent among controls.

Conclusions: Primary care COVID-19 diagnosis recorded in BIFAP showed that sensitivity was similar and PPV was slightly lower among vaccinated than unvaccinated controls. Among the elderly, COVID-19 diagnosis was less recorded. These findings permit the design of informed algorithms for performing COVID-19-related studies.

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疫苗接种状况对西班牙公共卫生系统药物流行病学研究数据库中COVID-19信息的验证
目的:验证西班牙公共卫生系统药物流行病学研究数据库(BIFAP)中的COVID-19信息记录。方法:从2020年12月至2021年10月期间接种COVID-19感染疫苗的患者及其匹配的未接种疫苗的对照组中,确定初级保健或阳性检测登记(金标准)中记录的COVID-19病例。评估初级保健记录的敏感性、特异性、阳性(PPV)和阴性(NPV)预测值。结果:在21702例阳性检测患者和20866例确诊病例中,疫苗组的敏感性、特异性、PPV和NPV分别为79.98%、99.95%、80.24%和99.94%,对照组的敏感性、特异性和PPV分别为78.67%、99.96%、84.51%和99.94%。结论:BIFAP记录的初级保健COVID-19诊断显示,接种疫苗组的敏感性相似,PPV略低于未接种疫苗的对照组。在老年人中,COVID-19的诊断记录较少。这些发现允许为开展covid -19相关研究设计知情算法。
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来源期刊
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1.90
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期刊介绍: Perspectives in Health Information Management is a scholarly, peer-reviewed research journal whose mission is to advance health information management practice and to encourage interdisciplinary collaboration between HIM professionals and others in disciplines supporting the advancement of the management of health information. The primary focus is to promote the linkage of practice, education, and research and to provide contributions to the understanding or improvement of health information management processes and outcomes.
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