The MIND diet, cognitive function, and well-being among healthy adults at midlife: a randomised feasibility trial.

IF 2.2 Q3 NUTRITION & DIETETICS BMC Nutrition Pub Date : 2025-03-25 DOI:10.1186/s40795-025-01020-6
Deirdre Timlin, Jacqueline M McCormack, Maeve Kerr, Laura Keaver, Ellen E A Simpson
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Abstract

Background: The Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to slow cognitive decline. However, these diets were not originally developed with dementia prevention as their primary focus. In contrast, the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was specifically designed based on evidence linking individual dietary components to brain health and the prevention of cognitive decline. The aim of this research was to test the effectiveness of the MIND diet on cognitive function, mood, and quality of life using the Behaviour Change Wheel, and to design an intervention using the COM-B model to promote the MIND diet at midlife.

Methods: An online pilot randomised control trial (RCT) was conducted. Forty-one participants (aged 40-55 years, male and female) were randomised into a MIND diet with support group (n = 15), MIND diet group with no support (n = 14) or control group (n = 12) for 12 weeks. Baseline and follow-up measures of cognitive function, mood, quality of life (QOL) and adherence to MIND diet was assessed in each group. Capability, opportunity, and motivation (COM-B) towards MIND diet behaviour were also assessed pre and post intervention.

Results: A repeated measures ANOVA showed that in comparison to the control group, both intervention groups significantly improved mood, quality of life, MIND diet score and all COM-B components at follow-up (p < 0.05). No significant differences or interactions in cognitive function were found between groups.

Conclusion: There are only two RCT's that test the effectiveness of the MIND diet on cognitive function, and this is the first RCT to assess the usefulness of the COM-B in increasing adherence to the MIND diet. Future interventions with longer duration are needed to establish an association with MIND diet and cognitive function in adults at midlife. This study recommends using less Behaviour Change Techniques (BCTs) with a focus on self-monitoring, goal setting and education on diet as an effective strategy for promoting adherence to the MIND diet.

Trial registration: Trial registered at ClinicalTrials.gov Protocol Record NCT04654936, May 2019.

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中年健康成年人的MIND饮食、认知功能和幸福感:一项随机可行性试验
背景:地中海和饮食方法停止高血压(DASH)饮食已被证明可以减缓认知能力下降。然而,这些饮食最初并不是以预防痴呆症为主要重点。相比之下,地中海- dash干预神经退行性延迟(MIND)饮食是专门根据个体饮食成分与大脑健康和预防认知能力下降之间的联系而设计的。本研究的目的是使用行为改变轮测试MIND饮食对认知功能、情绪和生活质量的有效性,并使用COM-B模型设计干预措施,以促进中年时的MIND饮食。方法:采用在线先导随机对照试验(RCT)。41名参与者(年龄在40-55岁之间,男性和女性)被随机分为有支持的MIND饮食组(n = 15)、无支持的MIND饮食组(n = 14)或对照组(n = 12),为期12周。对每组患者的认知功能、情绪、生活质量(QOL)和MIND饮食依从性的基线和随访测量进行评估。干预前后还评估了MIND饮食行为的能力、机会和动机(COM-B)。结果:重复测量方差分析显示,与对照组相比,两个干预组在随访中都显著改善了情绪、生活质量、MIND饮食评分和所有COM-B成分(p)。结论:只有两个RCT测试了MIND饮食对认知功能的有效性,这是第一个评估COM-B在增加MIND饮食依从性方面有用性的RCT。未来需要更长时间的干预措施来确定MIND饮食与中年成年人认知功能的关系。这项研究建议少使用行为改变技巧(bct),将重点放在自我监控、目标设定和饮食教育上,作为促进坚持MIND饮食的有效策略。试验注册:试验注册于ClinicalTrials.gov协议记录NCT04654936, 2019年5月。
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来源期刊
BMC Nutrition
BMC Nutrition Medicine-Public Health, Environmental and Occupational Health
CiteScore
2.80
自引率
0.00%
发文量
131
审稿时长
15 weeks
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