Chinenye C Odo, Joe Strong, Sarah R Lose, Yue Ma, Catherine L Gallagher, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nathaniel A Chin, Sanjay Asthana, Sterling C Johnson, Jacqueline Pontes Monteiro, Ozioma C Okonkwo
{"title":"Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD.","authors":"Chinenye C Odo, Joe Strong, Sarah R Lose, Yue Ma, Catherine L Gallagher, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nathaniel A Chin, Sanjay Asthana, Sterling C Johnson, Jacqueline Pontes Monteiro, Ozioma C Okonkwo","doi":"10.1002/dad2.70086","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Elevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation.</p><p><strong>Methods: </strong>RPP was cross-sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late-middle-aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of α-Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (Aβ)42/Aβ40, phosphorylated tau 181 (pTau181), and pTau181/Aβ4.</p><p><strong>Results: </strong>RPP was positively associated with NfL (β = 0.006, <i>R</i> <sup>2</sup> = 0.411, <i>p </i>= 0.012, but Bonferroni-corrected <i>p</i> ≤ 0.006) and not with other CSF biomarkers of neurodegeneration and neuroinflammation investigated in this sample.</p><p><strong>Discussion: </strong>A high myocardial oxygen demand at rest may be related to neuronal death and axonal degeneration in cognitively unimpaired late-middle-aged adults.</p><p><strong>Highlights: </strong>We explored the relationship between RPP and CSF analytes.Higher RPP was associated with higher NfL but not other measured CSF biomarkers.HR was positively associated with NfL, whereas SBP was not.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70086"},"PeriodicalIF":4.4000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934293/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70086","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Elevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation.
Methods: RPP was cross-sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late-middle-aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of α-Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (Aβ)42/Aβ40, phosphorylated tau 181 (pTau181), and pTau181/Aβ4.
Results: RPP was positively associated with NfL (β = 0.006, R2 = 0.411, p = 0.012, but Bonferroni-corrected p ≤ 0.006) and not with other CSF biomarkers of neurodegeneration and neuroinflammation investigated in this sample.
Discussion: A high myocardial oxygen demand at rest may be related to neuronal death and axonal degeneration in cognitively unimpaired late-middle-aged adults.
Highlights: We explored the relationship between RPP and CSF analytes.Higher RPP was associated with higher NfL but not other measured CSF biomarkers.HR was positively associated with NfL, whereas SBP was not.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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