Persisting Motor Function Problems in Children With Oesophageal Atresia Associated With Surgical Approach and Sports

IF 2.1 4区医学 Q1 PEDIATRICS Acta Paediatrica Pub Date : 2025-03-26 DOI:10.1111/apa.70074

Anne-Fleur R. L. van Hal, Sophie de Munck, Tabitha P. L. Zanen – van den Adel, Joost van Rosmalen, Saskia J. Gischler, Hanneke IJsselstijn, John Vlot, Leontien C. C. Toussaint-Duyster

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Abstract

Aim

Children born with oesophageal atresia are at risk for impaired motor function, yet longitudinal data are lacking. This study aimed to assess overall motor functioning, motor domains and potential predictors at school age over time.

Methods

A prospective observational cohort study conducted within a tertiary university hospital's follow-up programme. Outcomes included overall motor performance and specific subdomains: manual dexterity, ball skills and balance.

Results

Data from 161 children (84% oesophageal atresia type C) assessed at 5, 8 and 12 years showed estimated mean (95% CI) z-scores of −0.61 (−0.79 to −0.44), −0.35 (−0.53 to −0.16) and −0.56 (−0.77 to −0.34), respectively. At all ages and across subdomains, the proportion of children with definite motor impairments was significantly higher than the normative population (all p < 0.05). Univariable analyses identified lower gestational age, longer anaesthetic exposure, no sports participation and lower socio-economic status (all p < 0.05) as risk factors for impaired motor functioning. Multivariable analyses identified sports participation (p = 0.005) and, at 8 years, absence of thoracotomy (p < 0.001) as independent predictors.

Conclusion

School-aged children born with oesophageal atresia remain at risk for persistent motor impairments. Encouraging sports participation is recommended, and further research is needed to explore the underlying mechanisms of motor impairment.

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与手术入路和运动相关的食管闭锁儿童的持续运动功能问题。

目的：先天性食道闭锁患儿存在运动功能受损的风险，但缺乏纵向数据。本研究旨在评估学龄儿童的整体运动功能、运动域和潜在的预测因素。方法：在某三级大学医院进行前瞻性观察队列研究。结果包括整体运动表现和特定子领域：手灵巧性、球技和平衡。结果：161名儿童（84%为C型食管闭锁）在5年、8年和12年的评估数据显示，估计平均（95% CI） z-score分别为-0.61（-0.79至-0.44）、-0.35（-0.53至-0.16）和-0.56（-0.77至-0.34）。在所有年龄段和各个子域，明确运动障碍儿童的比例显著高于正常人群（均p）。结论：食道闭锁学龄儿童仍有发生持续性运动障碍的风险。建议鼓励运动参与，并需要进一步的研究来探索运动损伤的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries