Iron-catalyzed regioselective carboazidation of alkenes for the synthesis of multi-substituted cyclobutylamines†

Abstract

Cyclobutylamines are versatile synthetic frameworks with significant applications in pharmaceuticals and natural products. Herein, we report an iron-catalyzed carboazidation of alkenes, enabling the regioselective synthesis of multi-substituted cyclobutylamines. This method features a broad substrate scope, excellent functional group tolerance, and versatile synthetic applications, providing a practical approach to constructing multi-substituted cyclobutylamines with a quaternary-substituted carbon center.