{"title":"Towards P2X4 Positron Emission Tomography Tracing","authors":"Stephanie Federico","doi":"10.1021/acs.jmedchem.5c00772","DOIUrl":null,"url":null,"abstract":"The P2X4 receptor is involved in immunological and inflammatory processes and potent antagonists are potentially useful for therapeutic, investigational, and diagnostic purposes. This Viewpoint summarizes the discovery of potent and selective P2X4 antagonists that bring researchers closer to obtaining valuable PET tracers for studying the P2X4 receptor.","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"49 1","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1021/acs.jmedchem.5c00772","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
The P2X4 receptor is involved in immunological and inflammatory processes and potent antagonists are potentially useful for therapeutic, investigational, and diagnostic purposes. This Viewpoint summarizes the discovery of potent and selective P2X4 antagonists that bring researchers closer to obtaining valuable PET tracers for studying the P2X4 receptor.
期刊介绍：
The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents.
The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.
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